Buy Opana ER 40mg (Oxymorphone) Online
Generic Name: oxymorphone hydrochloride
Dosage Form: tablet, extended release
USA: 8 to 24 hours
Canada: 12 to 24 hours
International Delivery: 3 to 6 Days Depending on Client / Patient Location
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Indications and Usage for Opana ER
Limitations of Use
- Because of the risks of addiction, abuse, and misuse with opioids, then even at recommended doses, and because of the greater risks of overdose and death with extended-release opioid formulations [see Warnings and Precautions, reserve Opana ER for use in patients for whom alternative treatment options (e.g., non-opioid analgesics or immediate-release opioids) are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain.
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Dosage and Administration
2.1 Important Dosage and Administration Instructions
Opana ER should be prescribed only by healthcare professionals who are knowledgeable in the use of potent opioids for the management of chronic pain.
- Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals [see Warnings and Precautions.
- Initiate the dosing regimen for each patient individually, taking into account the patient’s severity of pain, patient response, prior analgesic treatment experience, and risk factors for addiction, abuse, and misuse [see Warnings and Precautions.
- Monitor patients closely for respiratory depression, especially within the first 24-72 hours of initiating therapy and following dosage increases with Opana ER and adjust the dosage accordingly [see Warnings and Precautions.
Then instruct patients to swallow Opana ER tablets whole, one tablet at a time, with enough water to ensure complete swallowing immediately after placing in the mouth (see Patient Counseling Information). meanwhile crushing, chewing, or dissolving Opana ER tablets will result in uncontrolled delivery of oxymorphone and can lead to overdose or death [see Warnings and Precautions. Where to Buy Opana ER 40mg (Oxymorphone) Online.
Secondly, administer on an empty stomach, at least 1 hour prior to or 2 hours after eating.
Opana ER is administered orally every 12 hours.
2.2 Initial Dosing
Use of Opana ER as the First Opioid Analgesic
Initiate treatment with Opana ER with the 5 mg tablet orally every 12-hours.
Use of Opana ER in Patients who are not Opioid Tolerant
The starting dose for patients who are not opioid tolerant is Opana ER 5 mg orally every 12 hours.
Furthermore, Patients considered opioid tolerant are those taking, for one week or longer, at least 60 mg oral morphine per day, 25 mcg transdermal fentanyl per hour, 30 mg oral oxycodone per day, 8 mg oral hydromorphone per day, 25 mg oral oxymorphone per day, 60 mg oral hydrocodone per day, or an equianalgesic dose of another opioid. Buy Opana ER 40mg (Oxymorphone) Online
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Likewise, the use of higher starting doses in patients who are not opioid tolerant may cause fatal respiratory depression.
Conversion from OPANA to Opana ER
Conversion from Parenteral Oxymorphone to Opana ER
Subsequently, the absolute oral bioavailability of Opana ER is approximately 10%. So, convert patients receiving parenteral oxymorphone to Opana ER by administering 10 times the patient’s total daily parental oxymorphone dose as Opana ER in two equally divided doses (e.g., [IV dose x 10] divided by 2). In addition, patient variability with regards to opioid analgesic responses. And upon conversion monitor patients closely to evaluate for adequate analgesia and side effects.
OPANA ER extended-release tablets are for oral use and contain oxymorphone, a semi-synthetic opioid analgesic. OPANA ER extended-release tablets are supplied in 5 mg, 7.5 mg, 10 mg, 15 mg, 20 mg, 30 mg, and 40 mg tablet strengths for oral administration. The tablet strength describes the amount of oxymorphone hydrochloride per tablet.
Meanwhile, the tablets contain the following inactive ingredients. Which are hypromellose, polyethylene oxide, polyethylene glycol, α-tocopherol, citric acid, polyvinyl alcohol, titanium dioxide, macrogol and talc.
Additionally, the 5 mg, 7.5 mg and 30 mg tablets contain iron oxide red. The 7.5 mg tablets contain iron oxide black, and iron oxide yellow. The 10 mg tablets contain FD&C yellow No. 6. The 20 mg tablets contain FD&C blue No. 1, FD&C yellow No. 6, and D&C yellow No. 10. The 40 mg tablets contain FD&C yellow No. 6, and D&C yellow No. 10.
Finally, The chemical name of oxymorphone hydrochloride is 4, 5α -epoxy-3, 14-dihydroxy-17-methylmorphinan-6-one hydrochloride, a white or slightly off-white, odorless powder. which is sparingly soluble in alcohol and ether, but freely soluble in water. The molecular weight of oxymorphone hydrochloride is 337.80. The pKa1 and pKa2 of oxymorphone at 37°C are 8.17 and 9.54, respectively. The octanol/aqueous partition coefficient at 37°C and pH 7.4 is 0.98.